ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	POU2F3
Symbol Alias	OCT11, PLA-1, Skn-1a, Epoc-1
Approved Name	POU class 2 homeobox 3
Previous Name	POU domain class 2, transcription factor 3
Location	11q23.3
Position	chr11:120110903-120190653, +
External Links	HGNC: 19864 Entrez Gene: 25833 Ensembl: ENSG00000137709 UCSC: uc001pxc.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 15)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0046983	protein dimerization activity	Molecular Function		26
GO:0005515	protein binding	Molecular Function	IPI[12624109]	910
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function		132
GO:0005667	transcription factor complex	Cellular Component		51
GO:0005634	nucleus	Cellular Component		770
GO:0005737	cytoplasm	Cellular Component		690
GO:0005730	nucleolus	Cellular Component		243
GO:0006357	regulation of transcription from RNA polymerase II promoter	Biological Process	TAS[10473598]	42
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0030216	keratinocyte differentiation	Biological Process		9
GO:0008544	epidermis development	Biological Process	TAS[10473598]	12
GO:0043565	sequence-specific DNA binding	Molecular Function	IDA[9242494]	72
GO:0042060	wound healing	Biological Process		13
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process		131
GO:0043922	negative regulation by host of viral transcription	Biological Process	IDA[14645924]	2

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with POU2F3 (count: 92)

Gene Symbol	Pathway Count	Pathway List
SREBF1	8	protein dimerization activity; protein binding; sequence-specific DNA binding transcription factor activity; nucleus; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
CLOCK	7	protein dimerization activity; sequence-specific DNA binding transcription factor activity; transcription factor complex; nucleus; nucleolus; regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
HEY2	7	protein dimerization activity; protein binding; sequence-specific DNA binding transcription factor activity; nucleus; cytoplasm; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
TBX1	7	protein dimerization activity; sequence-specific DNA binding transcription factor activity; nucleus; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
TFAP2A	7	protein dimerization activity; protein binding; nucleus; cytoplasm; nucleolus; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
ETS1	7	protein binding; sequence-specific DNA binding transcription factor activity; transcription factor complex; nucleus; transcription, DNA-dependent; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
HNF1B	7	protein binding; sequence-specific DNA binding transcription factor activity; transcription factor complex; nucleus; nucleolus; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
HOXA9	7	protein binding; sequence-specific DNA binding transcription factor activity; transcription factor complex; nucleus; cytoplasm; transcription, DNA-dependent; sequence-specific DNA binding;
KDM1A	7	protein binding; sequence-specific DNA binding transcription factor activity; transcription factor complex; nucleus; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
MEN1	7	protein binding; nucleus; cytoplasm; nucleolus; transcription, DNA-dependent; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
MTA2	7	protein binding; sequence-specific DNA binding transcription factor activity; transcription factor complex; nucleus; nucleolus; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
NCOR1	7	protein binding; sequence-specific DNA binding transcription factor activity; transcription factor complex; nucleus; cytoplasm; transcription, DNA-dependent; sequence-specific DNA binding;
RELA	7	protein binding; sequence-specific DNA binding transcription factor activity; transcription factor complex; nucleus; cytoplasm; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
BSX	7	sequence-specific DNA binding transcription factor activity; transcription factor complex; nucleus; cytoplasm; transcription, DNA-dependent; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
HOXB1	7	sequence-specific DNA binding transcription factor activity; nucleus; cytoplasm; nucleolus; transcription, DNA-dependent; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
AATF	6	protein binding; sequence-specific DNA binding transcription factor activity; nucleus; cytoplasm; nucleolus; positive regulation of transcription from RNA polymerase II promoter;
ATF6	6	protein binding; sequence-specific DNA binding transcription factor activity; nucleus; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; sequence-specific DNA binding;
ATXN1	6	protein binding; nucleus; cytoplasm; nucleolus; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
E2F5	6	protein binding; sequence-specific DNA binding transcription factor activity; transcription factor complex; cytoplasm; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
ELK3	6	protein binding; sequence-specific DNA binding transcription factor activity; nucleus; nucleolus; transcription, DNA-dependent; wound healing;
HES1	6	protein binding; sequence-specific DNA binding transcription factor activity; nucleus; cytoplasm; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
HOXA1	6	protein binding; sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
HOXA5	6	protein binding; sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
KAT5	6	protein binding; transcription factor complex; nucleus; nucleolus; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
NR4A2	6	protein binding; nucleus; cytoplasm; transcription, DNA-dependent; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
RBPJ	6	protein binding; sequence-specific DNA binding transcription factor activity; nucleus; cytoplasm; nucleolus; positive regulation of transcription from RNA polymerase II promoter;
SAP18	6	protein binding; nucleus; cytoplasm; nucleolus; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent;
SMARCB1	6	protein binding; nucleus; nucleolus; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
SUB1	6	protein binding; transcription factor complex; nucleus; nucleolus; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent;
TCF25	6	protein binding; sequence-specific DNA binding transcription factor activity; nucleus; cytoplasm; nucleolus; transcription, DNA-dependent;
YAP1	6	protein binding; transcription factor complex; nucleus; cytoplasm; keratinocyte differentiation; positive regulation of transcription from RNA polymerase II promoter;
FOXD4	6	sequence-specific DNA binding transcription factor activity; transcription factor complex; nucleus; nucleolus; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
HOXA11	6	sequence-specific DNA binding transcription factor activity; transcription factor complex; cytoplasm; nucleolus; transcription, DNA-dependent; sequence-specific DNA binding;
HOXA2	6	sequence-specific DNA binding transcription factor activity; nucleus; nucleolus; transcription, DNA-dependent; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
IKZF1	6	sequence-specific DNA binding transcription factor activity; nucleus; cytoplasm; transcription, DNA-dependent; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
TFEB	6	sequence-specific DNA binding transcription factor activity; transcription factor complex; nucleus; cytoplasm; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
ZNF367	6	sequence-specific DNA binding transcription factor activity; nucleus; cytoplasm; nucleolus; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent;
FOXP1	6	transcription factor complex; nucleus; cytoplasm; nucleolus; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
ERBB2	5	protein dimerization activity; protein binding; nucleus; transcription, DNA-dependent; wound healing;
HES6	5	protein dimerization activity; sequence-specific DNA binding transcription factor activity; transcription factor complex; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent;
ID2	5	protein dimerization activity; protein binding; nucleus; cytoplasm; nucleolus;
NPAS2	5	protein dimerization activity; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
NPAS3	5	protein dimerization activity; nucleus; cytoplasm; nucleolus; transcription, DNA-dependent;
WWOX	5	protein dimerization activity; protein binding; nucleus; cytoplasm; positive regulation of transcription from RNA polymerase II promoter;
BATF2	5	protein binding; sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; sequence-specific DNA binding;
BCLAF1	5	protein binding; nucleus; cytoplasm; nucleolus; transcription, DNA-dependent;
CBFA2T3	5	protein binding; sequence-specific DNA binding transcription factor activity; nucleolus; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
CREBZF	5	protein binding; sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; sequence-specific DNA binding;
CTNND1	5	protein binding; nucleus; cytoplasm; transcription, DNA-dependent; keratinocyte differentiation;
DAXX	5	protein binding; nucleus; cytoplasm; nucleolus; transcription, DNA-dependent;
DEAF1	5	protein binding; transcription factor complex; nucleus; cytoplasm; regulation of transcription from RNA polymerase II promoter;
FLII	5	protein binding; nucleus; cytoplasm; nucleolus; transcription, DNA-dependent;
FOXG1	5	protein binding; transcription factor complex; nucleus; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
GATA6	5	protein binding; sequence-specific DNA binding transcription factor activity; transcription factor complex; nucleus; positive regulation of transcription from RNA polymerase II promoter;
GSK3B	5	protein binding; nucleus; cytoplasm; nucleolus; positive regulation of transcription from RNA polymerase II promoter;
HINFP	5	protein binding; sequence-specific DNA binding transcription factor activity; nucleus; nucleolus; transcription, DNA-dependent;
HIRA	5	protein binding; sequence-specific DNA binding transcription factor activity; nucleus; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent;
HMGA1	5	protein binding; sequence-specific DNA binding transcription factor activity; transcription factor complex; nucleus; transcription, DNA-dependent;
HOXA10	5	protein binding; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcription, DNA-dependent; sequence-specific DNA binding;
LMX1B	5	protein binding; sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; sequence-specific DNA binding;
MAPK1	5	protein binding; nucleus; cytoplasm; nucleolus; transcription, DNA-dependent;
MED1	5	protein binding; nucleus; nucleolus; keratinocyte differentiation; positive regulation of transcription from RNA polymerase II promoter;
MEIS2	5	protein binding; sequence-specific DNA binding transcription factor activity; nucleus; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
NCOA6	5	protein binding; transcription factor complex; nucleus; nucleolus; positive regulation of transcription from RNA polymerase II promoter;
PGR	5	protein binding; nucleus; cytoplasm; nucleolus; sequence-specific DNA binding;
PRKCB	5	protein binding; nucleus; cytoplasm; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent;
PSPC1	5	protein binding; nucleus; cytoplasm; nucleolus; transcription, DNA-dependent;
RBM14	5	protein binding; transcription factor complex; nucleus; nucleolus; positive regulation of transcription from RNA polymerase II promoter;
RPS6KA4	5	protein binding; nucleus; cytoplasm; nucleolus; positive regulation of transcription from RNA polymerase II promoter;
RRP8	5	protein binding; nucleus; cytoplasm; nucleolus; transcription, DNA-dependent;
SMARCD3	5	protein binding; nucleus; cytoplasm; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent;
SNW1	5	protein binding; nucleus; nucleolus; regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
STRN3	5	protein binding; sequence-specific DNA binding transcription factor activity; nucleus; cytoplasm; positive regulation of transcription from RNA polymerase II promoter;
TARDBP	5	protein binding; sequence-specific DNA binding transcription factor activity; nucleus; nucleolus; negative regulation by host of viral transcription;
UTF1	5	protein binding; nucleus; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
XRCC5	5	protein binding; nucleus; cytoplasm; nucleolus; transcription, DNA-dependent;
ZNF24	5	protein binding; sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; sequence-specific DNA binding;
FOXC2	5	sequence-specific DNA binding transcription factor activity; transcription factor complex; nucleus; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
FOXE1	5	sequence-specific DNA binding transcription factor activity; transcription factor complex; nucleus; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
HOXA13	5	sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
HOXA3	5	sequence-specific DNA binding transcription factor activity; nucleus; nucleolus; transcription, DNA-dependent; sequence-specific DNA binding;
HOXA7	5	sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
HSF2	5	sequence-specific DNA binding transcription factor activity; nucleus; cytoplasm; nucleolus; positive regulation of transcription from RNA polymerase II promoter;
IRX3	5	sequence-specific DNA binding transcription factor activity; nucleus; cytoplasm; transcription, DNA-dependent; sequence-specific DNA binding;
LHX2	5	sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
MAF	5	sequence-specific DNA binding transcription factor activity; nucleus; cytoplasm; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
MTA3	5	sequence-specific DNA binding transcription factor activity; nucleus; cytoplasm; nucleolus; sequence-specific DNA binding;
ONECUT2	5	sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
PKNOX2	5	sequence-specific DNA binding transcription factor activity; nucleus; cytoplasm; regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
PRDM1	5	sequence-specific DNA binding transcription factor activity; nucleus; cytoplasm; transcription, DNA-dependent; sequence-specific DNA binding;
ZNF263	5	sequence-specific DNA binding transcription factor activity; nucleus; cytoplasm; nucleolus; transcription, DNA-dependent;
LPIN1	5	transcription factor complex; nucleus; cytoplasm; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;

Genes shared at least 2 KEGG pathways with POU2F3 (count: 0)

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Region: chr11:120110903..120190653 View in gBrowse