ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	HOXA2
Previous Symbol	HOX1K
Approved Name	homeobox A2
Previous Name	homeo box A2
Location	7p15.2
Position	chr7:27139973-27142394, -
External Links	HGNC: 5103 Entrez Gene: 3199 Ensembl: ENSG00000105996 UCSC: uc003syh.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
7p15	chr7:20900000-28800000	2 (1/1/0)

Gene related GO terms (count: 19)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 19)

ID	Name	Type	No. of Genes in ADHDgene
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	131
GO:0045665	negative regulation of neuron differentiation	Biological Process	13
GO:0048703	embryonic viscerocranium morphogenesis	Biological Process	5
GO:0035284	brain segmentation	Biological Process	1
GO:0021658	rhombomere 3 morphogenesis	Biological Process	1
GO:0043565	sequence-specific DNA binding	Molecular Function	72
GO:0042474	middle ear morphogenesis	Biological Process	4
GO:0009952	anterior/posterior pattern specification	Biological Process	26
GO:0008045	motor neuron axon guidance	Biological Process	7
GO:0021568	rhombomere 2 development	Biological Process	1
GO:0009953	dorsal/ventral pattern formation	Biological Process	12
GO:0001709	cell fate determination	Biological Process	2
GO:0005730	nucleolus	Cellular Component	243
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	78
GO:0005634	nucleus	Cellular Component	770
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function	132
GO:0007379	segment specification	Biological Process	1
GO:0002076	osteoblast development	Biological Process	4
GO:0006351	transcription, DNA-dependent	Biological Process	247

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with HOXA2 (count: 44)

Gene Symbol	Pathway Count	Pathway List
TBX1	8	positive regulation of transcription from RNA polymerase II promoter; embryonic viscerocranium morphogenesis; sequence-specific DNA binding; middle ear morphogenesis; anterior/posterior pattern specification; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent;
HNF1B	7	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; anterior/posterior pattern specification; nucleolus; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity;
HOXA1	7	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; anterior/posterior pattern specification; motor neuron axon guidance; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent;
HOXA7	7	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; anterior/posterior pattern specification; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent;
HOXB1	7	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; anterior/posterior pattern specification; nucleolus; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent;
MEN1	7	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; nucleolus; negative regulation of transcription from RNA polymerase II promoter; nucleus; osteoblast development; transcription, DNA-dependent;
LHX1	7	embryonic viscerocranium morphogenesis; sequence-specific DNA binding; anterior/posterior pattern specification; motor neuron axon guidance; dorsal/ventral pattern formation; nucleus; sequence-specific DNA binding transcription factor activity;
FOXC2	6	positive regulation of transcription from RNA polymerase II promoter; embryonic viscerocranium morphogenesis; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity;
HOXA5	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; anterior/posterior pattern specification; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent;
IKZF1	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent;
LHX2	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; dorsal/ventral pattern formation; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent;
MTA2	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; nucleolus; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity;
POU2F3	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; nucleolus; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent;
SREBF1	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent;
HOXA11	6	sequence-specific DNA binding; anterior/posterior pattern specification; dorsal/ventral pattern formation; nucleolus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent;
HOXA3	6	sequence-specific DNA binding; anterior/posterior pattern specification; nucleolus; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent;
BSX	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent;
ETS1	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent;
FOXD4	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; nucleolus; nucleus; sequence-specific DNA binding transcription factor activity;
FOXE1	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity;
FOXG1	5	positive regulation of transcription from RNA polymerase II promoter; negative regulation of neuron differentiation; sequence-specific DNA binding; dorsal/ventral pattern formation; nucleus;
FOXP1	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; motor neuron axon guidance; nucleolus; nucleus;
HES1	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity;
HEY2	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity;
HOXA13	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent;
ISL1	5	positive regulation of transcription from RNA polymerase II promoter; negative regulation of neuron differentiation; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity;
KAT5	5	positive regulation of transcription from RNA polymerase II promoter; nucleolus; negative regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent;
KDM1A	5	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent;
MAF	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity;
MED1	5	positive regulation of transcription from RNA polymerase II promoter; negative regulation of neuron differentiation; nucleolus; negative regulation of transcription from RNA polymerase II promoter; nucleus;
MEIS2	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity;
ONECUT2	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent;
RBPJ	5	positive regulation of transcription from RNA polymerase II promoter; nucleolus; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity;
TFAP2A	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; nucleolus; negative regulation of transcription from RNA polymerase II promoter; nucleus;
IRX3	5	negative regulation of neuron differentiation; sequence-specific DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent;
DRAP1	5	sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent;
HOXA4	5	sequence-specific DNA binding; anterior/posterior pattern specification; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent;
HOXA6	5	sequence-specific DNA binding; anterior/posterior pattern specification; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent;
HOXA9	5	sequence-specific DNA binding; anterior/posterior pattern specification; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent;
LMX1B	5	sequence-specific DNA binding; dorsal/ventral pattern formation; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent;
NCOR1	5	sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent;
PRDM1	5	sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent;
HOXB3	5	anterior/posterior pattern specification; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent;
TCF25	5	nucleolus; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent;

Genes shared at least 2 KEGG pathways with HOXA2 (count: 0)

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Region: chr7:27139973..27142394 View in gBrowse