ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	LHX1
Symbol Alias	LIM-1, LIM1
Approved Name	LIM homeobox 1
Location	17q12
Position	chr17:35294499-35301912, +
External Links	HGNC: 6593 Entrez Gene: 3975 Ensembl: ENSG00000132130 UCSC: uc002hnh.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 3)

ID	Location	Size	Band	Type	Inheritance
CNV_Elia[2010]_191	chr17:31889664-33323543 (NCBI Build 35 (hg17))	1774728	17q12	Deletion (hemizygous)	Paternal
CNV_Williams[2010]_7	chr17:31964475-33297438 (NCBI Build 36.1 (hg18))	1278621	17q12	Gain	Paternal
CNV_Williams[2010]_8	chr17:31979521-33318471 (NCBI Build 36.1 (hg18))	1276993	17q12	Loss

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 71)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 71)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0007399	nervous system development	Biological Process	TAS[9212161]	54
GO:0008045	motor neuron axon guidance	Biological Process		7
GO:0008270	zinc ion binding	Molecular Function		323
GO:0009653	anatomical structure morphogenesis	Biological Process		26
GO:0005634	nucleus	Cellular Component		770
GO:0006366	transcription from RNA polymerase II promoter	Biological Process		62
GO:0007267	cell-cell signaling	Biological Process		38
GO:0007389	pattern specification process	Biological Process		13
GO:0001764	neuron migration	Biological Process		21
GO:0001822	kidney development	Biological Process		16
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function		132
GO:0003714	transcription corepressor activity	Molecular Function		29
GO:0001658	branching involved in ureteric bud morphogenesis	Biological Process		8
GO:0001702	gastrulation with mouth forming second	Biological Process		5
GO:0001705	ectoderm formation	Biological Process		1
GO:0001706	endoderm formation	Biological Process		3
GO:0001071	nucleic acid binding transcription factor activity	Molecular Function		1
GO:0001657	ureteric bud development	Biological Process		4
GO:0001655	urogenital system development	Biological Process		1
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process		80
GO:0048646	anatomical structure formation involved in morphogenesis	Biological Process		1
GO:0044344	cellular response to fibroblast growth factor stimulus	Biological Process		3
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process		64
GO:0060059	embryonic retina morphogenesis in camera-type eye	Biological Process		3
GO:0060065	uterus development	Biological Process		1
GO:0048703	embryonic viscerocranium morphogenesis	Biological Process		5
GO:0048793	pronephros development	Biological Process		2
GO:0035847	uterine epithelium development	Biological Process		1
GO:0035849	nephric duct elongation	Biological Process		1
GO:0035502	metanephric part of ureteric bud development	Biological Process		1
GO:0035846	oviduct epithelium development	Biological Process		1
GO:0043234	protein complex	Cellular Component		45
GO:0043565	sequence-specific DNA binding	Molecular Function		72
GO:0035852	horizontal cell localization	Biological Process		1
GO:0040019	positive regulation of embryonic development	Biological Process		1
GO:0021549	cerebellum development	Biological Process		4
GO:0021537	telencephalon development	Biological Process		4
GO:0021527	spinal cord association neuron differentiation	Biological Process		2
GO:0021517	ventral spinal cord development	Biological Process		2
GO:0032525	somite rostral/caudal axis specification	Biological Process		2
GO:0021937	cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation	Biological Process		1
GO:0021871	forebrain regionalization	Biological Process		1
GO:0021702	cerebellar Purkinje cell differentiation	Biological Process		3
GO:0009948	anterior/posterior axis specification	Biological Process		3
GO:0009887	organ morphogenesis	Biological Process	TAS[7700351]	19
GO:0009880	embryonic pattern specification	Biological Process		5
GO:0009791	post-embryonic development	Biological Process		16
GO:0010842	retina layer formation	Biological Process		3
GO:0010468	regulation of gene expression	Biological Process		7
GO:0009953	dorsal/ventral pattern formation	Biological Process		12
GO:0009952	anterior/posterior pattern specification	Biological Process		26
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	Biological Process		5
GO:2000543	positive regulation of gastrulation	Biological Process		1
GO:2000744	positive regulation of anterior head development	Biological Process		1
GO:2000768	positive regulation of nephron tubule epithelial cell differentiation	Biological Process		1
GO:0072177	mesonephric duct development	Biological Process		2
GO:0072077	renal vesicle morphogenesis	Biological Process		1
GO:0072224	metanephric glomerulus development	Biological Process		2
GO:0072178	nephric duct morphogenesis	Biological Process		1
GO:0072283	metanephric renal vesicle morphogenesis	Biological Process		1
GO:0072278	metanephric comma-shaped body morphogenesis	Biological Process		1
GO:0090009	primitive streak formation	Biological Process		1
GO:0072284	metanephric S-shaped body morphogenesis	Biological Process		1
GO:0060067	cervix development	Biological Process		1
GO:0060066	oviduct development	Biological Process		1
GO:0060322	head development	Biological Process		3
GO:0060068	vagina development	Biological Process		1
GO:0061205	paramesonephric duct development	Biological Process		1
GO:0060429	epithelium development	Biological Process		1
GO:0072050	S-shaped body morphogenesis	Biological Process		2
GO:0072049	comma-shaped body morphogenesis	Biological Process		2

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with LHX1 (count: 35)

Gene Symbol	Pathway Count	Pathway List
HES1	8	nervous system development; nucleus; sequence-specific DNA binding transcription factor activity; negative regulation of transcription, DNA-dependent; sequence-specific DNA binding; telencephalon development; S-shaped body morphogenesis; comma-shaped body morphogenesis;
HOXA11	8	anatomical structure morphogenesis; sequence-specific DNA binding transcription factor activity; branching involved in ureteric bud morphogenesis; positive regulation of transcription, DNA-dependent; protein complex; sequence-specific DNA binding; dorsal/ventral pattern formation; anterior/posterior pattern specification;
TBX1	8	nucleus; pattern specification process; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; cellular response to fibroblast growth factor stimulus; embryonic viscerocranium morphogenesis; sequence-specific DNA binding; anterior/posterior pattern specification;
TFAP2A	8	nucleus; transcription from RNA polymerase II promoter; kidney development; positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; sequence-specific DNA binding; embryonic pattern specification; retina layer formation;
FOXP1	7	motor neuron axon guidance; zinc ion binding; nucleus; pattern specification process; negative regulation of transcription, DNA-dependent; sequence-specific DNA binding; ventral spinal cord development;
HOXA2	7	motor neuron axon guidance; nucleus; sequence-specific DNA binding transcription factor activity; embryonic viscerocranium morphogenesis; sequence-specific DNA binding; dorsal/ventral pattern formation; anterior/posterior pattern specification;
FOXP2	7	zinc ion binding; pattern specification process; sequence-specific DNA binding transcription factor activity; negative regulation of transcription, DNA-dependent; sequence-specific DNA binding; cerebellum development; post-embryonic development;
FOXE1	7	anatomical structure morphogenesis; nucleus; pattern specification process; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; sequence-specific DNA binding;
HNF1B	7	nucleus; kidney development; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; pronephros development; sequence-specific DNA binding; anterior/posterior pattern specification;
HOXA1	6	motor neuron axon guidance; anatomical structure morphogenesis; nucleus; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; anterior/posterior pattern specification;
CREB5	6	zinc ion binding; nucleus; transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding;
HINFP	6	zinc ion binding; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; regulation of gene expression;
LHX2	6	zinc ion binding; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding; dorsal/ventral pattern formation;
RREB1	6	zinc ion binding; nucleus; transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent;
ZBTB16	6	zinc ion binding; nucleus; positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; embryonic pattern specification; anterior/posterior pattern specification;
FEV	6	nucleus; transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; transcription corepressor activity; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding;
FOXC2	6	nucleus; sequence-specific DNA binding transcription factor activity; ureteric bud development; positive regulation of transcription, DNA-dependent; embryonic viscerocranium morphogenesis; sequence-specific DNA binding;
RELA	6	nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; sequence-specific DNA binding; organ morphogenesis;
ZNF423	5	nervous system development; zinc ion binding; nucleus; positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent;
GATA6	5	zinc ion binding; nucleus; transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; negative regulation of transcription, DNA-dependent;
KLF4	5	zinc ion binding; transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent;
LMX1B	5	zinc ion binding; nucleus; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; dorsal/ventral pattern formation;
MLL	5	zinc ion binding; nucleus; transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent;
NR4A2	5	zinc ion binding; nucleus; neuron migration; sequence-specific DNA binding; post-embryonic development;
NSD1	5	zinc ion binding; nucleus; transcription corepressor activity; gastrulation with mouth forming second; positive regulation of transcription, DNA-dependent;
ZNF24	5	zinc ion binding; nucleus; sequence-specific DNA binding transcription factor activity; negative regulation of transcription, DNA-dependent; sequence-specific DNA binding;
HOXA4	5	anatomical structure morphogenesis; nucleus; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; anterior/posterior pattern specification;
ETS1	5	nucleus; transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding;
FOXL1	5	nucleus; pattern specification process; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; organ morphogenesis;
HEY2	5	nucleus; sequence-specific DNA binding transcription factor activity; negative regulation of transcription, DNA-dependent; sequence-specific DNA binding; anterior/posterior axis specification;
HOXA7	5	nucleus; sequence-specific DNA binding transcription factor activity; negative regulation of transcription, DNA-dependent; sequence-specific DNA binding; anterior/posterior pattern specification;
HOXB1	5	nucleus; pattern specification process; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; anterior/posterior pattern specification;
MEIS2	5	nucleus; transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; transcription corepressor activity; sequence-specific DNA binding;
NCOR1	5	nucleus; transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; transcription corepressor activity; sequence-specific DNA binding;
NPAT	5	nucleus; sequence-specific DNA binding transcription factor activity; transcription corepressor activity; positive regulation of transcription, DNA-dependent; regulation of gene expression;

Genes shared at least 2 KEGG pathways with LHX1 (count: 0)

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Region: chr17:35294499..35301912 View in gBrowse