ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	FOXG1
Previous Symbol	FKHL2, FOXG1B, FKHL4, FKH2, FKHL1, FOXG1C, FKHL3, FOXG1A
Symbol Alias	HFK2, QIN, BF1, HFK1, HFK3, HBF-3
Approved Name	forkhead box G1
Previous Name	forkhead box G1B, "forkhead box G1C", "forkhead box G1A"
Location	14q11-q13
Position	chr14:29235050-29239479, +
External Links	HGNC: 3811 Entrez Gene: 2290 Ensembl: ENSG00000176165 UCSC: uc001wqe.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
14q12	chr14:24600000-33300000	1 (1/0/0)

Gene related GO terms (count: 29)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 29)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process		131
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity	Biological Process		16
GO:0045787	positive regulation of cell cycle	Biological Process		7
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	IDA[12657635]	64
GO:0043584	nose development	Biological Process		1
GO:0045665	negative regulation of neuron differentiation	Biological Process		13
GO:0042472	inner ear morphogenesis	Biological Process		6
GO:0043565	sequence-specific DNA binding	Molecular Function		72
GO:0030902	hindbrain development	Biological Process		3
GO:0035058	nonmotile primary cilium assembly	Biological Process		2
GO:0008301	DNA binding, bending	Molecular Function		9
GO:0008134	transcription factor binding	Molecular Function		38
GO:0009888	tissue development	Biological Process		4
GO:0009792	embryo development ending in birth or egg hatching	Biological Process		2
GO:0016199	axon midline choice point recognition	Biological Process		2
GO:0009953	dorsal/ventral pattern formation	Biological Process		12
GO:0030900	forebrain development	Biological Process		9
GO:0021954	central nervous system neuron development	Biological Process		3
GO:0005515	protein binding	Molecular Function	IPI[12657635]	910
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	Molecular Function		15
GO:0005667	transcription factor complex	Cellular Component		51
GO:0005634	nucleus	Cellular Component		770
GO:0007346	regulation of mitotic cell cycle	Biological Process		6
GO:0006355	regulation of transcription, DNA-dependent	Biological Process		158
GO:0007568	aging	Biological Process		29
GO:0007420	brain development	Biological Process	TAS[7599184]	33
GO:0002052	positive regulation of neuroblast proliferation	Biological Process		4
GO:0003677	DNA binding	Molecular Function	TAS[7959731]	220
GO:0003690	double-stranded DNA binding	Molecular Function		17

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with FOXG1 (count: 49)

Gene Symbol	Pathway Count	Pathway List
FOXE1	11	positive regulation of transcription from RNA polymerase II promoter; regulation of sequence-specific DNA binding transcription factor activity; negative regulation of transcription, DNA-dependent; sequence-specific DNA binding; DNA binding, bending; transcription factor binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; transcription factor complex; nucleus; DNA binding; double-stranded DNA binding;
FOXF1	11	positive regulation of transcription from RNA polymerase II promoter; regulation of sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; DNA binding, bending; transcription factor binding; tissue development; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; transcription factor complex; nucleus; DNA binding; double-stranded DNA binding;
FOXL1	11	regulation of sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; DNA binding, bending; transcription factor binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; transcription factor complex; nucleus; regulation of transcription, DNA-dependent; brain development; DNA binding; double-stranded DNA binding;
FOXD4	10	positive regulation of transcription from RNA polymerase II promoter; regulation of sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; DNA binding, bending; transcription factor binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; transcription factor complex; nucleus; regulation of transcription, DNA-dependent; double-stranded DNA binding;
FOXP1	10	positive regulation of transcription from RNA polymerase II promoter; regulation of sequence-specific DNA binding transcription factor activity; negative regulation of transcription, DNA-dependent; sequence-specific DNA binding; DNA binding, bending; transcription factor binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; transcription factor complex; nucleus; double-stranded DNA binding;
RELA	10	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; sequence-specific DNA binding; transcription factor binding; protein binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; transcription factor complex; nucleus; aging; DNA binding;
FOXC2	9	positive regulation of transcription from RNA polymerase II promoter; regulation of sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; DNA binding, bending; transcription factor binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; transcription factor complex; nucleus; double-stranded DNA binding;
FOXP2	9	regulation of sequence-specific DNA binding transcription factor activity; negative regulation of transcription, DNA-dependent; sequence-specific DNA binding; DNA binding, bending; transcription factor binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; transcription factor complex; DNA binding; double-stranded DNA binding;
HNF1B	8	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; hindbrain development; protein binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; transcription factor complex; nucleus; DNA binding;
NR5A1	8	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; tissue development; protein binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; nucleus; DNA binding; double-stranded DNA binding;
FOXR1	8	regulation of sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; DNA binding, bending; transcription factor binding; tissue development; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; transcription factor complex; double-stranded DNA binding;
ETS1	7	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription factor binding; protein binding; transcription factor complex; nucleus; DNA binding;
GATA6	7	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; transcription factor binding; protein binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; transcription factor complex; nucleus;
HES1	7	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; sequence-specific DNA binding; transcription factor binding; protein binding; nucleus; DNA binding;
MEN1	7	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; sequence-specific DNA binding; protein binding; nucleus; brain development; double-stranded DNA binding;
HMGA1	7	negative regulation of transcription, DNA-dependent; transcription factor binding; protein binding; transcription factor complex; nucleus; regulation of transcription, DNA-dependent; DNA binding;
HEY2	6	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; sequence-specific DNA binding; transcription factor binding; protein binding; nucleus;
KDM1A	6	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; transcription factor binding; protein binding; transcription factor complex; nucleus;
MED1	6	positive regulation of transcription from RNA polymerase II promoter; negative regulation of neuron differentiation; transcription factor binding; protein binding; nucleus; brain development;
SREBF1	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; protein binding; nucleus; aging; DNA binding;
TFAP2A	6	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; inner ear morphogenesis; sequence-specific DNA binding; protein binding; nucleus;
CREBZF	6	regulation of sequence-specific DNA binding transcription factor activity; negative regulation of transcription, DNA-dependent; sequence-specific DNA binding; protein binding; nucleus; DNA binding;
ATXN1	5	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; protein binding; nucleus; DNA binding;
E2F5	5	positive regulation of transcription from RNA polymerase II promoter; transcription factor binding; protein binding; transcription factor complex; DNA binding;
ESRRA	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; protein binding; nucleus; DNA binding;
HOXA2	5	positive regulation of transcription from RNA polymerase II promoter; negative regulation of neuron differentiation; sequence-specific DNA binding; dorsal/ventral pattern formation; nucleus;
HOXA5	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; protein binding; nucleus; DNA binding;
HOXA7	5	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; sequence-specific DNA binding; transcription factor binding; nucleus;
HOXB1	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; nucleus; regulation of transcription, DNA-dependent; DNA binding;
IKZF1	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; forebrain development; nucleus; DNA binding;
KAT5	5	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; protein binding; transcription factor complex; nucleus;
MEIS2	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription factor binding; protein binding; nucleus;
MTA2	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; protein binding; transcription factor complex; nucleus;
MYB	5	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; protein binding; regulation of transcription, DNA-dependent; DNA binding;
NCOA6	5	positive regulation of transcription from RNA polymerase II promoter; protein binding; transcription factor complex; nucleus; brain development;
POU2F3	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; protein binding; transcription factor complex; nucleus;
RBPJ	5	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; protein binding; nucleus; DNA binding;
TBX1	5	positive regulation of transcription from RNA polymerase II promoter; inner ear morphogenesis; sequence-specific DNA binding; nucleus; DNA binding;
MAPK1	5	regulation of sequence-specific DNA binding transcription factor activity; transcription factor binding; protein binding; nucleus; DNA binding;
STK36	5	regulation of sequence-specific DNA binding transcription factor activity; transcription factor binding; protein binding; nucleus; brain development;
ID2	5	positive regulation of cell cycle; negative regulation of transcription, DNA-dependent; negative regulation of neuron differentiation; protein binding; nucleus;
NR4A3	5	positive regulation of cell cycle; sequence-specific DNA binding; transcription factor complex; nucleus; DNA binding;
DAXX	5	negative regulation of transcription, DNA-dependent; transcription factor binding; protein binding; nucleus; regulation of transcription, DNA-dependent;
HINFP	5	negative regulation of transcription, DNA-dependent; protein binding; nucleus; regulation of transcription, DNA-dependent; DNA binding;
XRCC5	5	negative regulation of transcription, DNA-dependent; protein binding; nucleus; DNA binding; double-stranded DNA binding;
ZNF24	5	negative regulation of transcription, DNA-dependent; sequence-specific DNA binding; protein binding; nucleus; DNA binding;
APBB1	5	negative regulation of neuron differentiation; transcription factor binding; protein binding; nucleus; regulation of transcription, DNA-dependent;
LMX1B	5	sequence-specific DNA binding; dorsal/ventral pattern formation; protein binding; nucleus; regulation of transcription, DNA-dependent;
IGHMBP2	5	transcription factor binding; protein binding; nucleus; regulation of transcription, DNA-dependent; DNA binding;

Genes shared at least 2 KEGG pathways with FOXG1 (count: 0)

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Region: chr14:29235050..29239479 View in gBrowse